Ivan King Selected Research

VNP 20009 (VNP20009)

1/2009	Tumor-targeted Salmonella typhimurium overexpressing cytosine deaminase: a novel, tumor-selective therapy.
7/2008	Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.
7/2005	Systemic administration of an attenuated, tumor-targeting Salmonella typhimurium to dogs with spontaneous neoplasia: phase I evaluation.
1/2004	Construction of VNP20009: a novel, genetically stable antibiotic-sensitive strain of tumor-targeting Salmonella for parenteral administration in humans.
7/2002	Tumor-targeted Salmonella expressing cytosine deaminase as an anticancer agent.

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Ivan King Research Topics

Disease

9	Neoplasms (Cancer) 05/2017 - 07/2002
2	Melanoma (Melanoma, Malignant) 07/2008 - 06/2007
2	Carcinoma (Carcinomatosis) 07/2008 - 06/2007
2	Leukemia 06/2007 - 07/2006
1	Hematologic Neoplasms (Hematological Malignancy) 05/2017
1	Central Nervous System Neoplasms 07/2007
1	Weight Loss (Weight Reduction) 07/2007
1	Colitis 07/2006
1	Hyperbilirubinemia 07/2006
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 07/2006
1	Sepsis (Septicemia) 07/2006
1	Mucositis 07/2006

Drug/Important Bio-Agent (IBA)

5	VNP 20009 (VNP20009)IBA 01/2009 - 07/2002
4	laromustine (VNP40101M)IBA 05/2017 - 06/2007
2	Alkylating AgentsIBA 05/2017 - 06/2007
2	Cytosine DeaminaseIBA 01/2009 - 07/2002
2	EnzymesIBA 07/2008 - 07/2002
2	ProdrugsIBA 07/2008 - 07/2002
1	Proteins (Proteins, Gene)FDA Link 01/2009
1	gamma-Glutamyl Hydrolase (Carboxypeptidase G2)IBA 07/2008
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 06/2007
1	fludarabineIBA 06/2007
1	IronIBA 07/2006
1	3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine)IBA 07/2006
1	Chelating AgentsIBA 07/2006
1	Cytarabine (Cytosar-U)FDA LinkGeneric 07/2006
1	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 07/2006
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2004
1	Antineoplastic Agents (Antineoplastics)IBA 07/2002
1	Fluorouracil (Carac)FDA LinkGeneric 07/2002

Therapy/Procedure

4	Therapeutics 01/2009 - 07/2005
1	Aftercare (After-Treatment) 07/2007
1	Intravenous Administration 07/2002